GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11190604 | 1 | rs10883508 | chr10:102294413 | SEC31B | chr10:102246403-102289636:- | -0.3 | -11.17 | 1.74E-27 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs10883509 | chr10:102296461 | SEC31B | chr10:102246403-102289636:- | -0.3 | -11.06 | 5.18E-27 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs10883510 | chr10:102297018 | SEC31B | chr10:102246403-102289636:- | -0.3 | -10.51 | 1.15E-24 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs10883511 | chr10:102299407 | SEC31B | chr10:102246403-102289636:- | -0.3 | -11.08 | 4.27E-27 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs10883512 | chr10:102308516 | SEC31B | chr10:102246403-102289636:- | -0.29 | -10.79 | 8.13E-26 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs10883513 | chr10:102316964 | SEC31B | chr10:102246403-102289636:- | -0.27 | -8.9 | 2.4E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs4363385 | 1 | rs10888527 | chr1:153001363 | SPRR1A | chr1:152956557-152958289:+ | -0.16 | -4.73 | 2.53E-6 | Inflammatory skin disease |
| BRCA | cis | rs1867631 | 1 | rs10889636 | chr1:67089924 | TCTEX1D1 | chr1:67218140-67244729:+ | -0.12 | -3.49 | 0.000504 | Menopause (age at onset) |
| BRCA | cis | rs1867631 | 1 | rs10889640 | chr1:67127851 | TCTEX1D1 | chr1:67218140-67244729:+ | 0.12 | 3.43 | 0.000622 | Menopause (age at onset) |
| BRCA | cis | rs2275426 | 1 | rs10890352 | chr1:46283628 | CCDC163P | chr1:45960581-45965646:- | -0.41 | -12.04 | 2.25E-31 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890352 | chr1:46283628 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.45 | 0.000576 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890352 | chr1:46283628 | MUTYH | chr1:45794915-45806142:- | 0.12 | 4.79 | 1.93E-6 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890354 | chr1:46305347 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.81 | 2.33E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890354 | chr1:46305347 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.42 | 0.000642 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10890354 | chr1:46305347 | MUTYH | chr1:45794915-45806142:- | 0.13 | 4.95 | 8.6E-7 | Body mass index |